LicoLife - 30 Capsules
Licolife extract powder is a natural antioxidant produced from Licorice roots(Glycyrrhiza Glabra) in an exclusive and unique extraction process, patented in the USA and Europe.
LicoLife is a breakthrough in the prevention of atherosclerosis, cardiovascular disease and strokes: LicoLife significantly reduces the level of oxidated cholesterol in the blood, thus preventing oxidated cholesterol from sticking to the walls of the arteries.
This significantly delays the formation of plaques and narrowing of the arteries.
1 capsule of LicoLife once a day:
- Effective in significantly delaying atherosclerosis.
- Increases the plasma resistance to oxidation.
- Increases the resistance of bad cholesterol to oxidation.
- Fights free radicals.
- Decreases the triglyceride.
- Decreases the systolic blood pressure.
LicoLife is natural and safe to use – NO SIDE EFFECTS
Ingredients:
- potato starch.
- 100 mg licorice extract powder.
- magnesium stiarat.
- Vegetal capsule (capsule from hypromellose).
Licorice root (Glycyrrhiza glabra) has a long history of use by cultures throughout the world, including the Greeks, Egyptians, Chinese and Hindus. It grows wild in southern and central Europe and is extensively cultivated in Russia, Spain, Persia and India. Licorice is widely used as a flavoring, not only for candy but also in cough drops, syrups, tonics and laxatives.
The root of Glycyrrhiza glabra has been used for centuries as antidotes, demulcents, expectorants, and remedies for allergic inflammation, as well as flavoring and sweetening agents in Asia and Europe .
Licorice contains glycyrrhizin, oleane triterpenoids, glucose, and flavonoids. Licolice root is known as a natural Antioxidant vitamin, being used for cholesterol prevention.
LicoLife is made from the Licorice root, obtained through a unique extraction process, which helps in cholesterol prevention. This product is found with glycyrrhizin removed; the product is called DGL (for "deglycyrrhizinated licorice"). The most widely reported side effects of glycyrrhizin use are hypertension and edema .
LicoLife, which is Deglycyrrhizinated licorice, is used with glycyrrhizin removed in order to avoid the side effects.
Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays a key role in the pathogenesis of atherosclerosis. Under oxidative stress high cholesterol (LDL) is exposed to oxidative modifications by arterial wall cells including macrophages. Oxidative stress also induces cellular-lipid peroxidation, resulting in the formation of 'oxidized macrophages', which demonstrate increased capacity to oxidize LDL and increased uptake of oxidized LDL, reducing high cholesterol and helping in cholesterol prevention. Macrophage-mediated oxidation of LDL depends on the balance between pro-oxidants and antioxidants in the lipoprotein and in the cells. LDL is protected from oxidation by antioxidants.
A large number of studies provide data suggesting that consumption of dietary antioxidants is associated with reduced risk for cardiovascular diseases by lowering high cholesterol level. Basic research provides plausible mechanisms by which dietary antioxidants might reduce the development of atherosclerosis. These mechanisms include inhibition of LDL oxidation, inhibition of cellular lipid peroxidation and consequently attenuation of cell-mediated oxidation of LDL. The Licorice root includes potent polyphenolic flavonoids. Consumption of some plant-derived flavonoids results in their absorption and appearance in plasma and tissues. The inverse relationship between dietary flavonoids consumption and cardiovascular diseases may be associated with the ability of flavonoids to attenuate LDL oxidation, macrophage foam cell formation and atherosclerosis. The effect of flavonoids on arterial cell-mediated oxidation of LDL is determined by their accumulation in the lipoprotein and in arterial cells, such as macrophages. Flavonoids can reduce high cholesterol - LDL lipid peroxidation by scavenging reactive oxygen/nitrogen species, chelation of transition metal ions and sparing of LDL-associated antioxidants.
Glabridin is a polyphenolic flavonoid and a main constituent in the hydrophobic fraction of licorice extract. It is well known for its beneficial effects on the skin through an inhibitory effect on melanogenesis and inflammation. It also has a wide range of biological activities, including antimicrobial, antiatherosclerotic, antinephritic, and cardiovascular protective activities. Recently, it was reported that glabridin has a protective effect on low-density lipoprotein oxidation, and this contributes to the antiathero-sclerotic effect of glabridin. In a study from Lipid Research Laboratory, Technion Faculty of Medicine,
The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel, demonstrated that Licorice consumption:
- reduced patients' plasma susceptibility to oxidation (by 19%).
- increased resistance of plasma LDL against three major atherogenic modifications: oxidation (by 55%), aggregation (by 28%), and retention, estimated as chondroitin sulfate binding ability (by 25%).
- reduced plasma cholesterol levels (by 5%), which was due to a 9% reduction in plasma LDL cholesterol levels.
- reduced (by 14%) plasma triacylglycerol levels.
After the 1 month of placebo consumption, these parameters reversed toward baseline levels. Licorice extract supplementation also reduced systolic blood pressure by 10%. Another study demonstrated that dietary supplementation of each E zero mouse with licorice (200 micrograms/d) or pure glabridin (20 micrograms/d) for 6 wk resulted in a substantial reduction in the susceptibility of their LDL to oxidation along with a reduction in the atherosclerotic lesion area.
Licorice extract has been known to have an anti-inflammatory effect, and various components of licorice extract, including glabridin, are reported to be involved in this effect by exerting an inhibitory effect on cyclooxygenase and lipoxygenase activities. Liver microsomal P450 enzymes are involved in the metabolism of endogenous substrates such as fatty acids, cholesterol, and steroids. These enzymes also carry out an important function in the catalysis and ultimate clearance of many structurally distinct xenobiotics such as drugs, pesticides, carcinogens, and environmental pollutants
The potent antioxidants licorice root extract and glabridin, an isoflavan purified from licorice root extract, were tested for their ability to modulate the activities of several cytochrome P450 (P450) enzymes. The data shows that glabridin can lead to mechanism-based inactivation or inhibition of the P450.Compounds such as drugs or nutrients that either compete with each other for metabolism by P450s or that inactivate P450 enzymes may thereby affect the bioavailability of certain drugs, potentially leading to some clinical manifestations.
In conclusion: LicoLife significantly reduces the level of oxidated cholesterol in the blood, thus preventing oxidated cholesterol from sticking to the walls of the arteries, and helping to lower cholsterol. This Antuoxidant supplement significantly delays the formation of plaques and narrowing of arteries. It helps also to decrease high blood pressure, and therefore is used as heart disease prevention.
